Associate Director/Sr. Manager, Health Economics & Outcomes Research-Oncology at Natera

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Position Summary We are seeking a strategic, analytical, and highly collaborative leader to serve as our Associate Director/Senior Manager of Health Economics & Outcomes Research (HEOR) Oncology. In this high-impact role, you will lead the development and execution of health economic and outcomes evidence demonstrating the clinical and economic value of Natera’s precision molecular diagnostic technologies across oncology and emerging indications. You will develop health economic models, generate real-world and clinical-trial evidence, lead HEOR publication initiatives, and translate complex clinical and economic data into compelling evidence supporting market access, reimbursement, payer adoption, clinical adoption, and commercialization. Working across Medical Affairs, Clinical Development, Biostatistics, Market Access, Commercial, Marketing, Regulatory, and Business Development, you will help integrate HEOR evidence throughout the product lifecycle—from clinical development and evidence generation through publication, reimbursement, and payer adoption. This is a strategic role for an experienced HEOR professional who combines strong technical capabilities with scientific communication, business acumen, and the ability to influence cross-functional evidence strategy. Why Join Us At Natera, you will have the opportunity to shape the economic evidence strategy supporting innovative precision diagnostics and biomarker-guided approaches to patient care. You will work at the intersection of clinical evidence, health economics, market access, and commercialization, translating clinical innovation into measurable value for patients, providers, health systems, and payers. You will collaborate with internal leaders, investigators, key opinion leaders, and external research partners to generate evidence capable of influencing reimbursement decisions, clinical adoption, health technology assessments, and healthcare policy across U.S. and global markets. Key Responsibilities  Health Economic Modeling & Value Demonstration: Lead the development, validation, and application of health economic models, including budget impact, cost-effectiveness, cost-utility, cost-consequence, ROI, decision-tree, Markov/state-transition, partitioned-survival, and other economic models. Develop scenario and sensitivity analyses that quantify the clinical and economic value of precision diagnostics across different payer and healthcare-system perspectives.  Clinical Development & HEOR Evidence Strategy: Partner with Clinical Development, Medical Affairs, Biostatistics, and other cross-functional teams to integrate HEOR objectives into prospective clinical studies, including healthcare resource utilization, economic endpoints, patient-reported outcomes, quality-of- life measures, cost-data collection, and real-world evidence strategies. Ensure evidence-generation plans anticipate future payer, reimbursement, and HTA requirements.  Real-World Evidence & Outcomes Research: Analyze clinical-trial, observational, and real-world datasets to evaluate healthcare resource utilization, cost of care, treatment pathways, diagnostic utilization, clinical utility, comparative effectiveness, patient outcomes, survival, budget impact, and quality-adjusted life years. Translate findings into actionable evidence supporting clinical, payer, and business decisions.  Publication & Scientific Evidence Leadership: Lead HEOR publication strategy and development of peer-reviewed manuscripts, scientific abstracts, conference posters, oral presentations, white papers, and technical reports. Coordinate publication plans and timelines with investigators, key opinion leaders, academic collaborators, and external research partners to ensure evidence generation is aligned with strategic business priorities. …

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